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Total Health Optimization


  • November 24, 2025

    Nucleus attempts to respond, but accidentally admits its own guilt

    I respond to Nucleus Genomics’s critique of my recent post by demonstrating that their own response admits to plagiarism, admits that Origin is not novel, and admits that their whitepaper is chock-full of errors. Continue reading

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  • November 21, 2025

    Concerns about the legitimacy and integrity of Nucleus Genomics

    In this article, I begin by documenting a series of bizarre and misleading claims made by Nucleus in their marketing material. Afterward, I discuss the allegations made about borderline fraudulent misrepresentation of their polygenic scores and their obvious plagiarism of a Herasight whitepaper for their own product. Continue reading

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  • October 17, 2025

    Visiting Balaji Srinivasan’s Network School in the Singapore-Johor Special Economic Zone

    I recently had the pleasure of accepting Balaji Srinivasan’s personal invitation to visit his new endeavor, Network School, for several days. Over that time, I lived in Network School’s residences, spoke with Balaji several times while getting quizzed on linear algebra, sweatily wandered around the surrounding environ, and ate five to ten mixed berry puddings… Continue reading

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  • October 5, 2025

    Errors in Palladium’s “How GDP Hides Industrial Decline”

    The article is fractally wrong — on every level of examination, from the specific to the conceptual, it is a pure masterclass in how not to analyze a complex topic, much like how the output of early GPT iterations was grammatically correct but often semantically incoherent. Continue reading

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  • September 27, 2025

    Cardiovascular disease is a solved problem

    Cardiovascular disease is the #1 cause of death in modern nations. For young adults in good health, preventative usage of LDL-lowering therapies eliminates future risk of cardiovascular disease. Continue reading

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About Me

Occasional writer.

Recent Posts

  • Nucleus attempts to respond, but accidentally admits its own guilt
  • Concerns about the legitimacy and integrity of Nucleus Genomics
  • Visiting Balaji Srinivasan’s Network School in the Singapore-Johor Special Economic Zone
  • Errors in Palladium’s “How GDP Hides Industrial Decline”
  • Cardiovascular disease is a solved problem

Recent Comments

  1. Nucleus attempts to respond, but accidentally admits its own guilt – Total Health Optimization on Concerns about the legitimacy and integrity of Nucleus GenomicsNovember 24, 2025

    […] response to my recent post, Concerns about the legitimacy and integrity of Nucleus Genomics, Stephan Cordogan, the lead author…

  2. totalhealth on Concerns about the legitimacy and integrity of Nucleus GenomicsNovember 23, 2025

    Unfortunately, given the attention that this post is getting I feel that it would be inappropriate for me to express…

  3. Pulkit on Concerns about the legitimacy and integrity of Nucleus GenomicsNovember 23, 2025

    Super interesting stuff. Since you’re looking to do this yourself, which company do you think offers the highest quality of…

  4. Eric Kernfeld on Concerns about the legitimacy and integrity of Nucleus GenomicsNovember 23, 2025

    Thank you for doing Brandolini’s work. This post is a valuable service to … I was gonna say the community,…

  5. totalhealth on Concerns about the legitimacy and integrity of Nucleus GenomicsNovember 22, 2025

    Re: plagiarism, I agree it’s not as though they just lifted entire sentences and published them as-is, but my accusation…